β-Chain extension: A new mode of carbon-carbon bond formation and chain extension by polyketide synthases

Russell J. Cox

doi:10.1002/cbic.201300660

β-Chain extension: A new mode of carbon-carbon bond formation and chain extension by polyketide synthases

Russell J. Cox^*

^*Korrespondierende*r Autor*in für diese Arbeit

Institut für Organische Chemie

University of Bristol

Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review

Abstract

The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.

Originalsprache	Englisch
Seiten (von - bis)	27-29
Seitenumfang	3
Fachzeitschrift	CHEMBIOCHEM
Jahrgang	15
Ausgabenummer	1
DOIs	https://doi.org/10.1002/cbic.201300660 https://doi.org/10.1002/cbic.201300660
Publikationsstatus	Veröffentlicht - 3 Jan. 2014

ASJC Scopus Sachgebiete

Biochemie
Molekularmedizin
Molekularbiologie
Organische Chemie

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abstract = "The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.",

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