Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling

Benjamin Stauch; Bernd Simon; Teodora Basile; Gisbert Schneider; Nisar P. Malek; Markus Kalesse; Teresa Carlomagno

doi:10.1002/anie.201000140

Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling

Benjamin Stauch^*, Bernd Simon, Teodora Basile, Gisbert Schneider, Nisar P. Malek, Markus Kalesse, Teresa Carlomagno

^*Korrespondierende*r Autor*in für diese Arbeit

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Abstract

chemical equation presentation Complex considerations: The proteasome plays a key role in diseases and is thus an appealing drug target. A structural model (see picture) of the proteasome as a complex with argyrin, a cyclic heptapeptide with antitumoral activity, provides a rationale for the high biological activity of this natural product. The structure-activity-relationship data available for the drug are discussed on the basis of this model.

Originalsprache	Englisch
Seiten (von - bis)	3934-3938
Seitenumfang	5
Fachzeitschrift	Angewandte Chemie - International Edition
Jahrgang	49
Ausgabenummer	23
DOIs	https://doi.org/10.1002/anie.201000140
Publikationsstatus	Veröffentlicht - 25 Mai 2010
Extern publiziert	Ja

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Allgemeine Chemie

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10.1002/anie.201000140

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Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling. / Stauch, Benjamin; Simon, Bernd; Basile, Teodora et al.
in: Angewandte Chemie - International Edition, Jahrgang 49, Nr. 23, 25.05.2010, S. 3934-3938.

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

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