Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Annabel C. Murphy; Daisuke Fukuda; Zhongshu Song; Joanne Hothersall; Russell J. Cox; Christine L. Willis; Christopher M. Thomas; Thomas J. Simpson

doi:10.1002/anie.201007029

Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Annabel C. Murphy
, Daisuke Fukuda
, Zhongshu Song
, Joanne Hothersall
, Russell J. Cox
, Christine L. Willis
, Christopher M. Thomas
, Thomas J. Simpson

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Abstract

New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.

Originalsprache	Englisch
Seiten (von - bis)	3271-3274
Seitenumfang	4
Fachzeitschrift	Angewandte Chemie
Jahrgang	50
Ausgabenummer	14
DOIs	https://doi.org/10.1002/anie.201007029 https://doi.org/10.1002/ange.201007029
Publikationsstatus	Veröffentlicht - 28 März 2011
Extern publiziert	Ja

UN-Ziele für nachhaltige Entwicklung (SDGs)

2015 einigten sich die UN-Mitgliedstaaten auf 17 globale Ziele für nachhaltige Entwicklung (Sustainable Development Goals, SDGs) zur Beendigung von Armut, zum Schutz des Planeten und zur Förderung des allgemeinen Wohlstands. Hiermit leisten wir einen Beitrag zu folgendem/n Ziel(en) für nachhaltige Entwicklung (SDGs):

SDG 14 Lebensraum Wasser

ASJC Scopus Sachgebiete

Katalyse
Allgemeine Chemie

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Murphy, A. C., Fukuda, D., Song, Z., Hothersall, J., Cox, R. J., Willis, C. L., Thomas, C. M., & Simpson, T. J. (2011). Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390. Angewandte Chemie , 50(14), 3271-3274. https://doi.org/10.1002/anie.201007029, https://doi.org/10.1002/ange.201007029

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