Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Sian M. Cooper; Russell J. Cox; John Crosby; Matthew P. Crump; Joanne Hothersall; Wanpen Laosripaiboon; Thomas J. Simpson; Christopher M. Thomas

doi:10.1039/b414781b

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Sian M. Cooper^*
, Russell J. Cox
, John Crosby
, Matthew P. Crump
, Joanne Hothersall
, Wanpen Laosripaiboon
, Thomas J. Simpson
, Christopher M. Thomas

^*Korrespondierende*r Autor*in für diese Arbeit

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

Originalsprache	Englisch
Seiten (von - bis)	1179-1181
Seitenumfang	3
Fachzeitschrift	Chemical communications
Ausgabenummer	9
DOIs	https://doi.org/10.1039/b414781b
Publikationsstatus	Veröffentlicht - 7 März 2005
Extern publiziert	Ja

ASJC Scopus Sachgebiete

Katalyse
Elektronische, optische und magnetische Materialien
Keramische und Verbundwerkstoffe
Allgemeine Chemie
Oberflächen, Beschichtungen und Folien
Metalle und Legierungen
Werkstoffchemie

Zugriff auf Dokument

10.1039/b414781b

Andere Dateien und Links

Link zur Publikation in Scopus

Dieses zitieren

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title = "Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster",

abstract = "Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.",

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AU - Crump, Matthew P.

AU - Hothersall, Joanne

AU - Laosripaiboon, Wanpen

AU - Simpson, Thomas J.

AU - Thomas, Christopher M.

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AB - Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

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