Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Christopher Heuer; Xin Jiang; Gali Ron; Orna Ternyak; Thomas Scheper; Janina Bahnemann; Ester Segal

doi:10.1039/d3cc04446g

Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Christopher Heuer
, Xin Jiang
, Gali Ron
, Orna Ternyak
, Thomas Scheper
, Janina Bahnemann
, Ester Segal^*

^*Korrespondierende*r Autor*in für diese Arbeit

Institut für Technische Chemie

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Abstract

We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

Originalsprache	Englisch
Seiten (von - bis)	1305-1308
Seitenumfang	4
Fachzeitschrift	Chemical communications
Jahrgang	60
Ausgabenummer	10
DOIs	https://doi.org/10.1039/d3cc04446g
Publikationsstatus	Veröffentlicht - 27 Dez. 2023

ASJC Scopus Sachgebiete

Elektronische, optische und magnetische Materialien
Katalyse
Keramische und Verbundwerkstoffe
Allgemeine Chemie
Oberflächen, Beschichtungen und Folien
Metalle und Legierungen
Werkstoffchemie

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10.1039/d3cc04446gLizenz: CC BY-NC 3.0

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1 Dissertation

Silicon-Based Optical Sensors for Fungal Pathogen Diagnostics
Heuer, C., 24 Jan. 2024, Hannover: Leibniz Universität Hannover. 131 S.
Publikation: Qualifikations-/Studienabschlussarbeit › Dissertation

Open Access

1 Abgeschlossen

Ein universelles markierungsfreies Sensorsystem basierend auf Aptameren und porösem Silizium - Teil 2
Scheper, T. (Projektleiter*in (Principal Investigator)) & Beutel, S. (Projektleiter*in (Principal Investigator))
1 Feb. 2020 → 31 März 2023
Projekt: Forschung

Dieses zitieren

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title = "Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris",

abstract = "We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.",

author = "Christopher Heuer and Xin Jiang and Gali Ron and Orna Ternyak and Thomas Scheper and Janina Bahnemann and Ester Segal",

note = "Funding Information: This work was supported by the Israel Science Foundation (grant No. 2458/21). We also acknowledge funding by the German Research Foundation (DFG) via the Emmy Noether program (project ID346772917), and grant SCHE 279/32-2, as well as by the VolkswagenStiftung via the program {\textquoteleft}{\textquoteleft}Niedersa¨chsisches Vorab: Research Cooperation Lower Saxony— Israel{\textquoteright}{\textquoteright}. The authors thank the staff of the Micro- and Nanofabrication and Printing Unit (MNFPU) at the Technion for the fabrication of the photonic silicon chips.",

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AU - Heuer, Christopher

AU - Jiang, Xin

AU - Ron, Gali

AU - Ternyak, Orna

AU - Scheper, Thomas

AU - Bahnemann, Janina

AU - Segal, Ester

N1 - Funding Information: This work was supported by the Israel Science Foundation (grant No. 2458/21). We also acknowledge funding by the German Research Foundation (DFG) via the Emmy Noether program (project ID346772917), and grant SCHE 279/32-2, as well as by the VolkswagenStiftung via the program ‘‘Niedersa¨chsisches Vorab: Research Cooperation Lower Saxony— Israel’’. The authors thank the staff of the Micro- and Nanofabrication and Printing Unit (MNFPU) at the Technion for the fabrication of the photonic silicon chips.

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N2 - We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

AB - We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

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Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Abstract

ASJC Scopus Sachgebiete

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Andere Dateien und Links

Publikationen

Silicon-Based Optical Sensors for Fungal Pathogen Diagnostics

Projekte

Ein universelles markierungsfreies Sensorsystem basierend auf Aptameren und porösem Silizium - Teil 2

Dieses zitieren