TY - JOUR
T1 - RGD-Modified Titanium as an Improved Osteoinductive Biomaterial for Use in Dental and Orthopedic Implants
AU - Seemann, Alexandra
AU - Akbaba, Sema
AU - Buchholz, Jessica
AU - Türkkan, Sibel
AU - Tezcaner, Ayşen
AU - Woche, Susanne K.
AU - Guggenberger, Georg
AU - Kirschning, Andreas
AU - Dräger, Gerald
N1 - Funding Information:
This work was in part funded by the BIOFABRICATION FOR NIFE initiative, which is financially supported by the ministry of Lower Saxony and the Volkswagen Stiftung. In addition, we acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) for the Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy; EXC 62).
PY - 2022/2/16
Y1 - 2022/2/16
N2 - This study describes the synthesis, surface analysis, and biological evaluation of bioactive titanium surfaces. The aim was to achieve an improved effect on osteoinduction in dental and orthopedic implants. For this purpose, a chemistry was developed, which allows to bind the bioactive cyclopeptide cRGDfK covalently to biomedically used titanium via polyethylene glycol linkers of different lengths. The chemical process is practicable, robust, and metal-free. The resulting chemically modified titanium plates show improved osteoinductive properties. The modification with cRGDfK targets the integrin αvβ3, which is highly expressed in osteoblasts and is essential for many basic functions in the development of bone tissue. The successful immobilization of cRGDfK on titanium surfaces has been demonstrated by contact angle measurements and X-ray photoelectron spectroscopy. We show in in vitro studies that the presence of the cRGDfK peptide on titanium surfaces has a positive effect on bone formation.
AB - This study describes the synthesis, surface analysis, and biological evaluation of bioactive titanium surfaces. The aim was to achieve an improved effect on osteoinduction in dental and orthopedic implants. For this purpose, a chemistry was developed, which allows to bind the bioactive cyclopeptide cRGDfK covalently to biomedically used titanium via polyethylene glycol linkers of different lengths. The chemical process is practicable, robust, and metal-free. The resulting chemically modified titanium plates show improved osteoinductive properties. The modification with cRGDfK targets the integrin αvβ3, which is highly expressed in osteoblasts and is essential for many basic functions in the development of bone tissue. The successful immobilization of cRGDfK on titanium surfaces has been demonstrated by contact angle measurements and X-ray photoelectron spectroscopy. We show in in vitro studies that the presence of the cRGDfK peptide on titanium surfaces has a positive effect on bone formation.
UR - https://www.scopus.com/pages/publications/85124157058
U2 - 10.1021/acs.bioconjchem.1c00509
DO - 10.1021/acs.bioconjchem.1c00509
M3 - Article
C2 - 35073056
AN - SCOPUS:85124157058
SN - 1043-1802
VL - 33
SP - 294
EP - 300
JO - Bioconjugate chemistry
JF - Bioconjugate chemistry
IS - 2
ER -