Soluble versus insoluble polymers as supports for the preparation of new glycosteroids: A practicability study

Two polymeric supports along with two different linkers for attachment to O-4 of carbohydrate-derived glycals were evaluated for the solid phase synthesis of new glycosteroids 9 and 16. From these studies it can be concluded that soluble MPEG-ethers are less well suited polymeric supports for automated synthesis of glycoconjugates. Furthermore, it was found that glycosylation proceeds with much higher selectivity with polymer-bound glycals 3a and 12 compared to the solution variant.