Synthesis of the C1-C17 macrolactone of tedanolide

Jorma Hassfeld; Ulrike Eggert; Markus Kalesse

doi:10.1055/s-2005-865302

Synthesis of the C1-C17 macrolactone of tedanolide

Jorma Hassfeld, Ulrike Eggert, Markus Kalesse^*

^*Korrespondierende*r Autor*in für diese Arbeit

Institut für Organische Chemie

Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review

Abstract

The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.

Originalsprache	Englisch
Seiten (von - bis)	1183-1199
Seitenumfang	17
Fachzeitschrift	Synthesis
Ausgabenummer	7
DOIs	https://doi.org/10.1055/s-2005-865302
Publikationsstatus	Veröffentlicht - 2 Mai 2005

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2015 einigten sich die UN-Mitgliedstaaten auf 17 globale Ziele für nachhaltige Entwicklung (Sustainable Development Goals, SDGs) zur Beendigung von Armut, zum Schutz des Planeten und zur Förderung des allgemeinen Wohlstands. Hiermit leisten wir einen Beitrag zu folgendem/n Ziel(en) für nachhaltige Entwicklung (SDGs):

SDG 14 Lebensraum Wasser

ASJC Scopus Sachgebiete

Katalyse
Organische Chemie

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10.1055/s-2005-865302

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abstract = "The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.",

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AB - The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.

KW - Aldol reactions

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KW - Tedanolide

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