Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Lena Möller; Christian Hess; Jiří Paleček; Yi Su; Axel Haverich; Andreas Kirschning; Gerald Dräger

doi:10.3762/bjoc.9.33

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Lena Möller
, Christian Hess
, Jiří Paleček
, Yi Su
, Axel Haverich
, Andreas Kirschning
, Gerald Dräger^*

^*Korrespondierende*r Autor*in für diese Arbeit

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Abstract

Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

Originalsprache	Englisch
Seiten (von - bis)	270-277
Seitenumfang	8
Fachzeitschrift	Beilstein Journal of Organic Chemistry
Jahrgang	9
DOIs	https://doi.org/10.3762/bjoc.9.33
Publikationsstatus	Veröffentlicht - 8 Feb. 2013

ASJC Scopus Sachgebiete

Organische Chemie

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10.3762/bjoc.9.33

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AU - Hess, Christian

AU - Paleček, Jiří

AU - Su, Yi

AU - Haverich, Axel

AU - Kirschning, Andreas

AU - Dräger, Gerald

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AB - Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

KW - Click chemistry

KW - Growth factor

KW - Nitrenes

KW - Plasma chemistry

KW - Poly(4-methylpent-1-ene)

KW - Surface modification

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