@article{f5aba8c4bd344f64abfb29c87f58a727,
title = "Towards the total synthesis of tonantzitlolone - Preparation of key fragments and the complete carbon backbone",
abstract = "The first synthetic advances towards the novel diterpenoid tonantzitlolone 1 are described. The key steps in the synthesis involve a chromium(II) Reformatsky reaction, a diastereoselective C1 extension and an expeditious aldol coupling step of two advanced precursors.",
keywords = "Chromium Reformatsky reaction, Formylation, Polymer-supported reagents, Terpene, Total synthesis",
author = "R{\"u}diger Wittenberg and Christian Beier and Gerald Dr{\"a}ger and Gerhard Jas and Christian Jasper and Holger Monenschein and Andreas Kirschning",
note = "Funding information: This research was supported by a graduate fellowship provided by the state of Lower Saxony for R.W. and by a Kekul{\'e} scholarship for C.J. provided by the Stiftung Stipendien-Fonds des Verbandes der Chemischen Industrie. We are grateful to Dr. Jasmin Jakupovic (AnalytiCon Discovery GmbH, Potsdam) for providing us with details on Tonantzitlolone. Finally, we thank the Fonds der Chemischen Industrie for general support.",
year = "2004",
month = may,
day = "6",
doi = "10.1016/j.tetlet.2004.04.056",
language = "English",
volume = "45",
pages = "4457--4460",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "23",
}