Analyzing randomized dose finding studies with a primary and a secondary endpoint

Ludwig A. Hothorn; Gernot Wassmer

doi:10.1081/BIP-120019273

Analyzing randomized dose finding studies with a primary and a secondary endpoint

Ludwig A. Hothorn^*
, Gernot Wassmer

^*Corresponding author for this work

Department of Biostatistics

University of Cologne

Research output: Contribution to journal › Article › Research › peer review

Abstract

The identification of the minimum effective dose for both the primary and secondary endpoint under a priori importance ordering assumption is described. Stepwise testing procedures, which conditionally test each elementary hypotheses at level α, but control the experimentwise Type I error rate, can be used.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	Journal of Biopharmaceutical Statistics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1081/BIP-120019273
Publication status	Published - 4 Jan 2003

Keywords

Dose finding trial
Intersection-union test
Multiple endpoints

ASJC Scopus subject areas

Statistics and Probability
Pharmacology
Pharmacology (medical)

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10.1081/BIP-120019273

Cite this

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abstract = "The identification of the minimum effective dose for both the primary and secondary endpoint under a priori importance ordering assumption is described. Stepwise testing procedures, which conditionally test each elementary hypotheses at level α, but control the experimentwise Type I error rate, can be used.",

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KW - Dose finding trial

KW - Intersection-union test

KW - Multiple endpoints

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M3 - Article

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Analyzing randomized dose finding studies with a primary and a secondary endpoint

Abstract

Keywords

ASJC Scopus subject areas

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