Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Annabel C. Murphy; Daisuke Fukuda; Zhongshu Song; Joanne Hothersall; Russell J. Cox; Christine L. Willis; Christopher M. Thomas; Thomas J. Simpson

doi:10.1002/anie.201007029

Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Annabel C. Murphy
, Daisuke Fukuda
, Zhongshu Song
, Joanne Hothersall
, Russell J. Cox
, Christine L. Willis
, Christopher M. Thomas
, Thomas J. Simpson

Research output: Contribution to journal › Article › Research › peer review

Abstract

New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.

Original language	English
Pages (from-to)	3271-3274
Number of pages	4
Journal	Angewandte Chemie
Volume	50
Issue number	14
DOIs	https://doi.org/10.1002/anie.201007029 https://doi.org/10.1002/ange.201007029
Publication status	Published - 28 Mar 2011
Externally published	Yes

UN Sustainable Development Goals (SDGs)

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

antibiotics
biosynthesis
methicillin resistance
mupirocin
thiomarinol

ASJC Scopus subject areas

Catalysis
General Chemistry

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Murphy, A. C., Fukuda, D., Song, Z., Hothersall, J., Cox, R. J., Willis, C. L., Thomas, C. M., & Simpson, T. J. (2011). Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390. Angewandte Chemie , 50(14), 3271-3274. https://doi.org/10.1002/anie.201007029, https://doi.org/10.1002/ange.201007029

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abstract = "New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.",

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author = "Murphy, \{Annabel C.\} and Daisuke Fukuda and Zhongshu Song and Joanne Hothersall and Cox, \{Russell J.\} and Willis, \{Christine L.\} and Thomas, \{Christopher M.\} and Simpson, \{Thomas J.\}",

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AU - Murphy, Annabel C.

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AU - Hothersall, Joanne

AU - Cox, Russell J.

AU - Willis, Christine L.

AU - Thomas, Christopher M.

AU - Simpson, Thomas J.

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KW - biosynthesis

KW - methicillin resistance

KW - mupirocin

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ER -

Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Abstract

UN Sustainable Development Goals (SDGs)

Keywords

ASJC Scopus subject areas

Access to Document

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