Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Maria Leilani Torres-Mapa; Manmeet Singh; Olga Simon; Jose Louise Mapa; Manan Machida; Axel Günther; Bernhard Roth; Dag Heinemann; Mitsuhiro Terakawa; Alexander Heisterkamp

doi:10.3390/s19194333

Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Maria Leilani Torres-Mapa^*, Manmeet Singh, Olga Simon, Jose Louise Mapa, Manan Machida, Axel Günther, Bernhard Roth, Dag Heinemann, Mitsuhiro Terakawa, Alexander Heisterkamp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer review

Abstract

Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

Original language	English
Article number	4333
Journal	Sensors (Switzerland)
Volume	19
Issue number	19
DOIs	https://doi.org/10.3390/s19194333 https://doi.org/10.15488/9274
Publication status	Published - 1 Oct 2019

Keywords

3D printing
Fluorescence
Hydrogels
Microfluidics
Waveguide

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Atomic and Molecular Physics, and Optics
Instrumentation
Electrical and Electronic Engineering

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10.3390/s19194333Licence: CC BY 4.0
10.15488/9274Licence: CC BY 4.0

Cite this

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title = "Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing",

abstract = "Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.",

keywords = "3D printing, Fluorescence, Hydrogels, Microfluidics, Waveguide",

author = "Torres-Mapa, {Maria Leilani} and Manmeet Singh and Olga Simon and Mapa, {Jose Louise} and Manan Machida and Axel G{\"u}nther and Bernhard Roth and Dag Heinemann and Mitsuhiro Terakawa and Alexander Heisterkamp",

note = "Funding information: This work is supported by the Federal Ministry of Education and Research, Germany (13N14085) and the German Research Foundation, Germany Clusters of Excellence: REBIRTH (EXC 62) and Hearing4all (EXC 2177). Acknowledgments: The publication of this article was funded by the Open Access fund of Leibniz Universit{\"a}t Hannover. We would like to acknowledge Kotaro Obata for early support on PDMS material and Manuel Fernandez for 3D-printing of the molds.",

year = "2019",

month = oct,

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doi = "10.3390/s19194333",

language = "English",

volume = "19",

journal = "Sensors (Switzerland)",

issn = "1424-8220",

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AU - Torres-Mapa, Maria Leilani

AU - Singh, Manmeet

AU - Simon, Olga

AU - Mapa, Jose Louise

AU - Machida, Manan

AU - Günther, Axel

AU - Roth, Bernhard

AU - Heinemann, Dag

AU - Terakawa, Mitsuhiro

AU - Heisterkamp, Alexander

N1 - Funding information: This work is supported by the Federal Ministry of Education and Research, Germany (13N14085) and the German Research Foundation, Germany Clusters of Excellence: REBIRTH (EXC 62) and Hearing4all (EXC 2177). Acknowledgments: The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover. We would like to acknowledge Kotaro Obata for early support on PDMS material and Manuel Fernandez for 3D-printing of the molds.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

AB - Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

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Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cluster of Excellence 2177: Hearing4all

PhoenixD: Cluster of Excellence 2122/1: Photonics, Optics, and Engineering – Innovation Across Disciplines

REBIRTH: Cluster of Excellence 62/2: From Regenerative Biology to Reconstructive Therapy

Cite this

Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Projects

Cluster of Excellence 2177: Hearing4all

PhoenixD: Cluster of Excellence 2122/1: Photonics, Optics, and Engineering – Innovation Across Disciplines

REBIRTH: Cluster of Excellence 62/2: From Regenerative Biology to Reconstructive Therapy

Cite this