Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats

Sherif A. Abdelmottaleb Moussa; Fatma A.A. Ibrahim; Marawan Abd Elbaset; Fatma A. Morsy; Samir W. Aziz; Noha A. Abd El-Latif; Sherif M. Afifi; Tuba Esatbeyoglu; Sayed A. El Toumy; Josline Y. Salib; Samir A.E. Bashandy

doi:10.1016/j.endmts.2025.100235

Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats

Sherif A. Abdelmottaleb Moussa^*, Fatma A.A. Ibrahim, Marawan Abd Elbaset, Fatma A. Morsy, Samir W. Aziz, Noha A. Abd El-Latif, Sherif M. Afifi, Tuba Esatbeyoglu^*, Sayed A. El Toumy, Josline Y. Salib, Samir A.E. Bashandy

^*Corresponding author for this work

Institute of Food and One Health

Research output: Contribution to journal › Article › Research › peer review

Abstract

Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.

Original language	English
Article number	100235
Journal	Endocrine and Metabolic Science
Volume	18
E-pub ahead of print	31 Mar 2025
DOIs	https://doi.org/10.1016/j.endmts.2025.100235
Publication status	Published - Jun 2025

UN Sustainable Development Goals (SDGs)

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Insulin resistance
Liver
Obesity
Oxidative stress
Thyme

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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Abdelmottaleb Moussa, S. A., Ibrahim, F. A. A., Elbaset, M. A., Morsy, F. A., Aziz, S. W., Abd El-Latif, N. A., Afifi, S. M., Esatbeyoglu, T., El Toumy, S. A., Salib, J. Y., & Bashandy, S. A. E. (2025). Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats. Endocrine and Metabolic Science, 18, Article 100235. https://doi.org/10.1016/j.endmts.2025.100235

@article{d13a53c91d1f4065bdacccc8f37c41da,

title = "Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats",

abstract = "Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.",

keywords = "Insulin resistance, Liver, Obesity, Oxidative stress, Thyme",

author = "{Abdelmottaleb Moussa}, {Sherif A.} and Ibrahim, {Fatma A.A.} and Elbaset, {Marawan Abd} and Morsy, {Fatma A.} and Aziz, {Samir W.} and {Abd El-Latif}, {Noha A.} and Afifi, {Sherif M.} and Tuba Esatbeyoglu and {El Toumy}, {Sayed A.} and Salib, {Josline Y.} and Bashandy, {Samir A.E.}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = jun,

doi = "10.1016/j.endmts.2025.100235",

language = "English",

volume = "18",

journal = "Endocrine and Metabolic Science",

issn = "2666-3961",

publisher = "Elsevier BV",

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Abdelmottaleb Moussa, SA, Ibrahim, FAA, Elbaset, MA, Morsy, FA, Aziz, SW, Abd El-Latif, NA, Afifi, SM, Esatbeyoglu, T, El Toumy, SA, Salib, JY & Bashandy, SAE 2025, 'Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats', Endocrine and Metabolic Science, vol. 18, 100235. https://doi.org/10.1016/j.endmts.2025.100235

TY - JOUR

T1 - Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats

AU - Abdelmottaleb Moussa, Sherif A.

AU - Ibrahim, Fatma A.A.

AU - Elbaset, Marawan Abd

AU - Morsy, Fatma A.

AU - Aziz, Samir W.

AU - Abd El-Latif, Noha A.

AU - Afifi, Sherif M.

AU - Esatbeyoglu, Tuba

AU - El Toumy, Sayed A.

AU - Salib, Josline Y.

AU - Bashandy, Samir A.E.

PY - 2025/6

Y1 - 2025/6

N2 - Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.

AB - Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.

KW - Insulin resistance

KW - Liver

KW - Obesity

KW - Oxidative stress

KW - Thyme

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U2 - 10.1016/j.endmts.2025.100235

DO - 10.1016/j.endmts.2025.100235

M3 - Article

AN - SCOPUS:105001878624

SN - 2666-3961

VL - 18

JO - Endocrine and Metabolic Science

JF - Endocrine and Metabolic Science

M1 - 100235

ER -

Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats

Abstract

UN Sustainable Development Goals (SDGs)

Keywords

ASJC Scopus subject areas

Access to Document

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