Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Sian M. Cooper; Russell J. Cox; John Crosby; Matthew P. Crump; Joanne Hothersall; Wanpen Laosripaiboon; Thomas J. Simpson; Christopher M. Thomas

doi:10.1039/b414781b

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Sian M. Cooper^*
, Russell J. Cox
, John Crosby
, Matthew P. Crump
, Joanne Hothersall
, Wanpen Laosripaiboon
, Thomas J. Simpson
, Christopher M. Thomas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer review

Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

Original language	English
Pages (from-to)	1179-1181
Number of pages	3
Journal	Chemical communications
Issue number	9
DOIs	https://doi.org/10.1039/b414781b
Publication status	Published - 7 Mar 2005
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b414781b

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title = "Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster",

abstract = "Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.",

author = "Cooper, \{Sian M.\} and Cox, \{Russell J.\} and John Crosby and Crump, \{Matthew P.\} and Joanne Hothersall and Wanpen Laosripaiboon and Simpson, \{Thomas J.\} and Thomas, \{Christopher M.\}",

year = "2005",

month = mar,

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doi = "10.1039/b414781b",

language = "English",

pages = "1179--1181",

journal = "Chemical communications",

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publisher = "Chemical Society",

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AU - Cooper, Sian M.

AU - Cox, Russell J.

AU - Crosby, John

AU - Crump, Matthew P.

AU - Hothersall, Joanne

AU - Laosripaiboon, Wanpen

AU - Simpson, Thomas J.

AU - Thomas, Christopher M.

PY - 2005/3/7

Y1 - 2005/3/7

N2 - Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

AB - Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

UR - https://www.scopus.com/pages/publications/15444381232

U2 - 10.1039/b414781b

DO - 10.1039/b414781b

M3 - Article

C2 - 15726184

AN - SCOPUS:15444381232

SN - 1359-7345

SP - 1179

EP - 1181

JO - Chemical communications

JF - Chemical communications

IS - 9

ER -

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Abstract

ASJC Scopus subject areas

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