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Remarkable kinetic resolution of chiral β-keto esters by baker's yeast reduction

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Abstract

The reduction of chiral β-keto esters with baker's yeast is described. Reduction of 10 yields highly functionalized diol 11 with excellent stereoselectivity and generates a useful intermediate for natural product syntheses.

Original languageEnglish
Pages (from-to)837-838
Number of pages2
JournalSYNLETT
Volume1995
Issue number8
DOIs
Publication statusPublished - Aug 1995

Keywords

  • 1,3-diols
  • Baker's yeast reduction
  • kinetic resolution
  • β-keto esters

ASJC Scopus subject areas

  • Organic Chemistry

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