TY - UNPB
T1 - Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology
AU - Hothorn, Ludwig A.
AU - Spiliotopoulos, Dimitrios
PY - 2020/9/25
Y1 - 2020/9/25
N2 - To claim similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology is a relevant issue during the assay validation process. Here we demonstrated the use of dose-by-laboratory interaction contrasts, particularly Williams-type by total mean contrasts. With the CRAN packages statint and multcomp in the open-source software R the estimation of adjusted p-values or compatible simultaneous confidence intervals is relatively easy. The interpretation in terms of global or partial equivalence, i.e. similarity, is challenging, because thresholds are not available a-priori. This approach is demonstrated by selected in-vitro Ames MPF assay data.
AB - To claim similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology is a relevant issue during the assay validation process. Here we demonstrated the use of dose-by-laboratory interaction contrasts, particularly Williams-type by total mean contrasts. With the CRAN packages statint and multcomp in the open-source software R the estimation of adjusted p-values or compatible simultaneous confidence intervals is relatively easy. The interpretation in terms of global or partial equivalence, i.e. similarity, is challenging, because thresholds are not available a-priori. This approach is demonstrated by selected in-vitro Ames MPF assay data.
KW - stat.AP
U2 - 10.48550/arXiv.2009.12110
DO - 10.48550/arXiv.2009.12110
M3 - Preprint
BT - Similarity of multiple dose-response curves in interlaboratory studies in regulatory toxicology
ER -