Abstract
Recent advances in nanotechnology caused a growing interest using nanomaterials in medicine to solve a number of issues associated with therapeutic agents. The fabricated nanomaterials with unique physical and chemical properties have been investigated for both diagnostic and therapeutic applications. Therapeutic agents have been combined with the nanoparticles to minimize systemic toxicity, increase their solubility, prolong the circulation half-life, reduce their immunogenicity and improve their distribution. Multifunctional nanoparticles have shown great promise in targeted imaging and therapy. In this review, we summarized the physical parameters of nanoparticles for construction of "smart" multifunctional nanoparticles and their various surface engineering strategies. Outlook and questions for the further researches were discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 33-41 |
| Number of pages | 9 |
| Journal | BioNanoMaterials |
| Volume | 17 |
| Issue number | 1-2 |
| E-pub ahead of print | 28 Apr 2016 |
| DOIs | |
| Publication status | Published - 1 May 2016 |
Keywords
- drug delivery system
- medical applications
- nanomaterials
- nanomedicine
- nanoparticles
- targeting therapy
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering
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