The extracellular matrix of hematopoietic stem cell niches

Cornelia Lee-Thedieck; Peter Schertl; Gerd Klein

doi:10.1016/j.addr.2021.114069

The extracellular matrix of hematopoietic stem cell niches

Cornelia Lee-Thedieck^*
, Peter Schertl
, Gerd Klein

^*Corresponding author for this work

Department of Cell Biology

Universitätsklinikum Tübingen

Research output: Contribution to journal › Article › Research › peer review

Abstract

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.

Original language	English
Article number	114069
Journal	Advanced drug delivery reviews
Volume	181
E-pub ahead of print	25 Nov 2021
DOIs	https://doi.org/10.1016/j.addr.2021.114069
Publication status	Published - Feb 2022

Keywords

Bone marrow
Extracellular matrix
Hematopoietic stem cell niche

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.addr.2021.114069Licence: CC BY 4.0

Cite this

@article{2130afd23cbd4873b93d3d6251606f65,

title = "The extracellular matrix of hematopoietic stem cell niches",

abstract = "Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.",

keywords = "Bone marrow, Extracellular matrix, Hematopoietic stem cell niche",

author = "Cornelia Lee-Thedieck and Peter Schertl and Gerd Klein",

note = "Funding Information: This project has received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation programme (grant agreement No 757490). This work has been carried out within the framework of the SMART BIOTECS alliance between the Technische Universit{\"a}t Braunschweig and the Leibniz Universit{\"a}t Hannover. This initiative is supported by the Ministry of Science and Culture (MWK) of Lower Saxony, Germany.",

year = "2022",

month = feb,

doi = "10.1016/j.addr.2021.114069",

language = "English",

volume = "181",

journal = "Advanced drug delivery reviews",

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T1 - The extracellular matrix of hematopoietic stem cell niches

AU - Lee-Thedieck, Cornelia

AU - Schertl, Peter

AU - Klein, Gerd

N1 - Funding Information: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 757490). This work has been carried out within the framework of the SMART BIOTECS alliance between the Technische Universität Braunschweig and the Leibniz Universität Hannover. This initiative is supported by the Ministry of Science and Culture (MWK) of Lower Saxony, Germany.

PY - 2022/2

Y1 - 2022/2

N2 - Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.

AB - Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their function is controlled by their direct microenvironment, the HSC niche in the bone marrow. Although the importance of the extracellular matrix (ECM) in the niche by orchestrating niche architecture and cellular function is widely acknowledged, it is still underexplored. In this review, we provide a comprehensive overview of the ECM in HSC niches. For this purpose, we first briefly outline HSC niche biology and then review the role of the different classes of ECM molecules in the niche one by one and how they are perceived by cells. Matrix remodeling and the emerging importance of biophysics in HSC niche function are discussed. Finally, the application of the current knowledge of ECM in the niche in form of artificial HSC niches for HSC expansion or targeted differentiation as well as drug testing is reviewed.

KW - Bone marrow

KW - Extracellular matrix

KW - Hematopoietic stem cell niche

UR - https://www.scopus.com/pages/publications/85122640210

U2 - 10.1016/j.addr.2021.114069

DO - 10.1016/j.addr.2021.114069

M3 - Article

SN - 0169-409X

VL - 181

JO - Advanced drug delivery reviews

JF - Advanced drug delivery reviews

M1 - 114069

ER -

The extracellular matrix of hematopoietic stem cell niches

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

BloodANDbone: Blood and bone – conjoined twins in health and disease: bone marrow analogs for hematological and musculoskeletal diseases

Cite this

The extracellular matrix of hematopoietic stem cell niches

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Projects

BloodANDbone: Blood and bone – conjoined twins in health and disease: bone marrow analogs for hematological and musculoskeletal diseases

Cite this