Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Lena Möller; Christian Hess; Jiří Paleček; Yi Su; Axel Haverich; Andreas Kirschning; Gerald Dräger

doi:10.3762/bjoc.9.33

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Lena Möller
, Christian Hess
, Jiří Paleček
, Yi Su
, Axel Haverich
, Andreas Kirschning
, Gerald Dräger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer review

Abstract

Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

Original language	English
Pages (from-to)	270-277
Number of pages	8
Journal	Beilstein Journal of Organic Chemistry
Volume	9
DOIs	https://doi.org/10.3762/bjoc.9.33
Publication status	Published - 8 Feb 2013

Keywords

Click chemistry
Growth factor
Nitrenes
Plasma chemistry
Poly(4-methylpent-1-ene)
Surface modification

ASJC Scopus subject areas

Organic Chemistry

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10.3762/bjoc.9.33

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title = "Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide",

abstract = "Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free {"}click{"} approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.",

keywords = "Click chemistry, Growth factor, Nitrenes, Plasma chemistry, Poly(4-methylpent-1-ene), Surface modification",

author = "Lena M{\"o}ller and Christian Hess and Ji{\v r}{\'i} Pale{\v c}ek and Yi Su and Axel Haverich and Andreas Kirschning and Gerald Dr{\"a}ger",

year = "2013",

month = feb,

day = "8",

doi = "10.3762/bjoc.9.33",

language = "English",

volume = "9",

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journal = "Beilstein Journal of Organic Chemistry",

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T1 - Towards a biocompatible artificial lung

T2 - Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

AU - Möller, Lena

AU - Hess, Christian

AU - Paleček, Jiří

AU - Su, Yi

AU - Haverich, Axel

AU - Kirschning, Andreas

AU - Dräger, Gerald

PY - 2013/2/8

Y1 - 2013/2/8

N2 - Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

AB - Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free "click" approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

KW - Click chemistry

KW - Growth factor

KW - Nitrenes

KW - Plasma chemistry

KW - Poly(4-methylpent-1-ene)

KW - Surface modification

UR - https://www.scopus.com/pages/publications/84874637792

U2 - 10.3762/bjoc.9.33

DO - 10.3762/bjoc.9.33

M3 - Article

AN - SCOPUS:84874637792

SN - 1860-5397

VL - 9

SP - 270

EP - 277

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

ER -

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Abstract

Keywords

ASJC Scopus subject areas

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